Product Description

The Nose-only Inhalation Exposure System for large animals is suitable for oral and nasal administration and inhalation exposure experiments on large animals such as rabbits, dogs, and monkeys, using inhalable substances such as aerosols, and nanoparticles aerosols, and smoke. The system can ensure the consistency of the inhaled exposure dose of animals in the same experimental group; realize online concentration detection of aerosols and real-time online sampling of samples; adopt a high-precision control system to ensure the uniformity and stability of exposure. The animal exposure system can test a variety of different substances, including drugs, air pollutants, PM2.5, organic substances, industrial hygiene, agricultural chemicals, etc. It can carry out acute poisoning, chronic poisoning, low pressure, high pressure, hypoxia, hyperoxia, and other gas exposure experiments.

Features

1. Double-chamber design

2. Experimental channel: standard 8 -channel configuration

3. Each layer is removable for easy cleaning

4. Material: Stainless steel

5. Double-chamber design: the inner chamber is a drug aerosol, and the aerosol is directly transported to the channel; the outer chamber collects the exhaled gas of the animal. The separation of inner and outer cavities is to prevent re-inhalation of exhaled air by animals

6. Monitoring indicators: temperature, humidity, oxygen concentration, carbon dioxide concentration, pressure, drug concentration, aerosol particle size distribution, etc.

7. Automatic control

8. Adopt a high-precision mass flowmeter to accurately control the gas volume of each channel of the system

9. Sampling flow accuracy: 0.01L/min to ensure the accuracy of measurement

10. It has a professional multi-stage exhaust gas treatment module, and the exhaust gas can meet the laboratory safety emission requirements after treatment.

Application 

Respiratory disease modeling, drug efficacy evaluation, drug safety evaluation, inhalation toxicology research, environmental safety evaluation, PM2.5 research, chemical and pesticide safety evaluation, radioactive material hazard evaluation, military medicine, aerospace medicine, etc.

Configuration

Reference

[1]Fan Z, Zhou B, Liu Y, Sun W, Fang Y, Lu H, Chen D, Lu K, Wu X, Xiao T, Xie W, Bian Q. "Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents" . [J]. AAPS PharmSciTech. 2022 Jan 6;23(1):50. doi: 10.1208/s12249-021-02191-8.

[2]Jushan Zhang, Mo Xue, Rong Pan, Yujie Zhu, Zhongyang Zhang, Haoxiang Cheng, Johan L M Björkegren, Jia Chen, Zhiqiang Shi,Ke Hao“An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood” [J]. bioRxiv preprint doi . https://doi.org/10.1101/2022.10.12.511981;

[3]Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu,Xue-Qing Zhang,Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer,[J]ACS Applied Materials & Interfaces,2023-06-24 ,DOI:10.1021/acsami.3c05007

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  Nose-only Inhalation Exposure for Small Animal