Product Description

The simple nose-only aerosol drug delivery system is often used for animal model establishment and aerosol drug delivery research. The system can atomize and disperse liquid drugs into inhalable aerosols, and animals are exposed to an experimental chamber with a predetermined time and a certain concentration of a certain gas to complete the drug delivery process; it can also be used as a mouth-nose exposure system for animals. Oral and nasal exposure inhalation test. The system adopts an open design and is compatible with a variety of different aerosol generators, special gases, and pollutant sources. The use of the mouth-nose immobilizer enables the animals to inhale the medicine only through the mouth and nose, avoiding the adhesion of the fur to the medicine, and eliminating the effect of licking the hair leading to the second oral administration.

The high-frequency oscillation technology of microporous sieve is used in drug atomization, which replaces the traditional ultrasonic atomization and air jet atomization. There are thousands of precise micropores in the center of the atomization head. During atomization, the microporous sieve ejects the liquid medicine in the form of aerosol through high-frequency vibration. Aerosols have a particle size of 1-5 microns and can effectively enter the alveoli and are droplets that facilitate deep lung deposition.

Features

1. Eliminate the effects of secondary oral administration

2. Reduce drug wastage

3. Simultaneous administration of multiple animals

Application

Modeling and aerosol administration of respiratory diseases, such as bronchial asthma, pulmonary fibrosis, chronic bronchitis, lung injury, etc.

Configuration

Reference

 [1]Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents.Fan Z, Zhou B, Liu Y, Sun W, Fang Y, Lu H, Chen D, Lu K, Wu X, Xiao T, Xie W, Bian Q.AAPS PharmSciTech. 2022 Jan 6;23(1):50. doi: 10.1208/s12249-021-02191-8.

[2]Jushan Zhang, Mo Xue, Rong Pan, Yujie Zhu, Zhongyang Zhang, Haoxiang Cheng, Johan L M Björkegren, Jia Chen, Zhiqiang Shi,Ke Hao“An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood” [J]. bioRxiv preprint doi . https://doi.org/10.1101/2022.10.12.511981;

[3]Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu,Xue-Qing Zhang,Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer,[J]ACS Applied Materials & Interfaces,2023-06-24 ,DOI:10.1021/acsami.3c05007

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  Nose-only Inhalation Exposure for Small Animal