Product Description

Animal Hypobaric Chamber (Thermostatic Version) is used to simulate the hypobaric condition mimicking high plateau environment. The pressure can be set according to the needs, and the maximum altitude can be simulated up to 12,000 meters. It can accommodate several mouse cages or small to medium-sized animals such as dogs, monkeys, rabbits, mice, etc.

The whole experimental device is composed of animal chamber, vacuum system, monitoring and control system. The equipment has a high degree of automation and does not need special personnel to manage it, and it can work for a month or more.

Multifunctional

l Real-time display of altitude and oxygen concentration dynamic curve

l Multifunctional programming control: stage type, cycle type, cycle mode control

 l Experimental process data can be saved to U disk, and can be read in the computer analysis

l With automatic ventilation function, in line with animal feeding standards

l Provide multi-directional alarm function to remind lab assistant of abnormal state

Safety Guarantee

l From the beginning of design to the final completion of testing and inspection, all experimental oxygen chambers follow a strict production process;

l Features emergency shut-off and automatic exhaust system to adapt to various situations.

Animal Chamber

l The main body is made of imported acrylic thickened material, solid and reliable, transparent and easy to observe;

l Aluminum alloy and stainless steel material support;

l With castor foot brake design, easy to move.

Gas delivery control system

l High performance low noise vacuum system to provide stable pressure for the system;

l  It has a gas buffer, which can reduce or even eliminate the impact of thin jet stream gas on small animals.

l Perfect multistage air filter, to ensure that the air in the animal chamber will not pollute the experimental environment.

Additional Functional Modules and Customization

l Monitoring of Animal Physiological Indicators

lAchievable monitoring indicators: ECG, heart rate, body temperature, blood pressure, respiration, blood oxygen saturation;

l Respiratory metabolism monitoring function

l Blood collection function

l Video monitoring function

l Animal Hypoxic Treadmill

l Hypoxic forced swimming device

l Temperature control function

l Constant temperature function, temperature can be controlled, room temperature -40 ℃;

l Low temperature function, 4°C, temperature controllable, room temperature -4°C;

l Other functions can be customized

Application field

Altitude Sickness Research, research on pulmonary edema, cerebral edema, pulmonary hypertension and other diseases

Model Selection

Customer List

1. Army Medical University                                                              2. Academy of Military Medical Sciences

3. Air Force Medical University                                                       4. Henan University

5. Hunan Experimental Animal Center                                            6. Chengdu University of Chinese Medicine

7. The General Hospital of the People's Liberation Army (301 Hospital     8. China Pharmaceutical University

9. Peking University                                                                                      10. Lanzhou University

11. Sichuan Provincial People's Hospital                                                          12. Nantong University

13. Shanghai JiaoTong University Children's Medical Center                       14. Beijing Military Research Institute

15. Institute of Chinese Academy of Sciences                                                 16. Wuhan University

17. Hubei University of Chinese Medicine                                                       18. Daping Hospital

Reference

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J] European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner, [J] European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling, [J] Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J] Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Jing Zhang , Jian-Zhong Jiang , Jun Xu , Chen-Yu Xu , Shan Mao , Ying Shi , Wei Gu , Chun-Fang Zou , Yue-Ming Zhao , Liang Ye.”Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea”[J]Annals of Vascular Surgery, Available online 2 February 2023

[8]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[9]Zhang, L., Liu, X., Wei, Q. et al. “Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p. “[J]. Mamm Genome 34, 76–89 (2023).

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[12]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[14]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang“High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue.” [J]. Antioxidants 2022, 11, 2367.

[15]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.” [J]. bioRxiv preprint, 2023.03.23.533972

[16]Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qianqian Luo, Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348 

[17]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H, Luo, Q, He M, & Wang, G(2023).“ Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization.”[J]. Frontiers in Cellular Neuroscience, 17, 1152392. doi: 10.3389/fncel.2023.1152392

[18]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism.”[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018

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  Animal Hypobaric Chamber (Thermostatic Version)