Product Description

Animal Hypobaric Chamber (Thermostatic Version) is used to simulate the hypobaric condition mimicking high plateau environment. The pressure can be set according to the needs, and the maximum altitude can be simulated up to 12,000 meters. It can accommodate several mouse cages or small to medium-sized animals such as dogs, monkeys, rabbits, mice, etc.

The whole experimental device is composed of animal chamber, vacuum system, monitoring and control system. The equipment has a high degree of automation and does not need special personnel to manage it, and it can work for a month or more.

Product Features

User-friendly Design

l Adopt 10-inch touch screen, user-friendly interface design, easy to operate.

l Two control methods: automatic, manual, and controllable when power off; it has dual monitoring functions of sensor components and mechanical watches. The automatic program design of the equipment does not require special personnel to wait for it, and it can continue to operate for a long time.

l Real-time display of dynamic change curves of altitude and oxygen partial pressure.

l The experimental process data can be exported in csv format and saved to a USB-drive, and read and analyzed in the computer.

l According to the experimental needs of customers, the experimental environment and supporting other related experimental equipment can be customized.

l Equipped with a special low-pressure water bottle for animals to prevent water droplets from leaking too quickly in a negative pressure environment.

Safety Measures

l Equipped with automatic ventilation function, abide with Good Animal Feeding Practice.

l Provide multi-directional alarm function (temperature, humidity, pressure, oxygen concentration upper/lower limit) to prevent potential safety hazards. 

l Equipped with gradually opening hand-wheel hatch to reduce the damage caused by misoperation.

l The chamber is made of transparent thick acrylic material, which is convenient for researchers to observe the conditions of experimental animals.

l Equipped with a gas buffer, it reduces or even eliminates the impact of jet stream gas on small animals.

l Equipped with a multi-stage air filter to ensure that the experimental environment air in the animal cabin will not be polluted.

l The cabin simulates the bearing force analysis to ensure that the structure is safe enough.

Additional Functional Modules and Customization

l Monitoring of Animal Physiological Indicators

l Achievable monitoring indicators: ECG, heart rate, body temperature, blood pressure, respiration, blood oxygen saturation;

l Respiratory metabolism monitoring function

l Blood collection function

l Video monitoring function

l Animal Hypoxic Treadmill

l Hypoxic forced swimming device

l Temperature control function

l Constant temperature function, temperature can be controlled, room temperature -40 ℃;

l Low temperature function, 4°C, temperature controllable, room temperature -4°C;

l Other functions can be customized

Application field

Altitude Sickness Research, research on pulmonary edema, cerebral edema, pulmonary hypertension and other diseases

Model Selection

Customer List

1. Army Medical University

2. Academy of Military Medical Sciences

3. Air Force Medical University

4. Henan University

5. Hunan Experimental Animal Center

6. Chengdu University of Chinese Medicine

7. The General Hospital of the People's Liberation Army (301 Hospital

8. China Pharmaceutical University

9. Peking University

10. Lanzhou University

11. Sichuan Provincial People's Hospital

12. Nantong University

13. Shanghai JiaoTong University Children's Medical Center

14. Beijing Military Research Institute

15. Institute of Chinese Academy of Sciences

16. Wuhan University

17. Hubei University of Chinese Medicine

18. Daping Hospital

Reference

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling" . [J]. Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[8]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[9]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[10]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang“High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue.” [J]. Antioxidants 2022, 11, 2367.

[11]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.” [J]. bioRxiv preprint, 2023.03.23.533972

[12]Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qianqian Luo, Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348 

[13]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H, Luo, Q, He M, & Wang, G(2023).“ Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization.”[J]. Frontiers in Cellular Neuroscience, 17, 1152392. doi: 10.3389/fncel.2023.1152392

[14]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism.”[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018

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  Animal Hypobaric Chamber (Thermostatic Version)