Detailed Introduction

Whole-body Plethysmograph (WBP) can be used to measure lung function and airway response in large full-conscious and free moving laboratory animals, smartly exempting the need of traumatic tracheotomy and anesthesia.

Product Description

Whole-body Plethysmograph (WBP) can be used to measure lung function and airway response in large full-conscious and free moving laboratory animals, smartly exempting the need of traumatic tracheotomy and anesthesia, making the experimental process simple, quick, and suitable for long-term follow-up study.

Product Features

1.  Suitable for rabbits and canines

2. No surgery is required and the operation is simple

3. It can be used in the study of animal respiration in full-conscious state and long-term follow-up experiments and is suitable for preliminary drug screening

4. It has a drug aerosol nebulization module

5.  It comes with automatic calibration function

6. Feeding troughs can be provided for long-term continuous monitoring

7. Optional functions are available, for example the measurements of ECG, blood pressure, body temperature, heart rate and other vital signs, which can be combined with implantable telemetry equipment

8. Equipped with analysis software, data can be saved in Excel or TXT format (Customization is available catering to customers' specific requirements)

Test Parameters

Ti: Inspiratory Time (s)

Te: Expiratory Time (s)

PIF: Peak Inspiratory Flow (ml/s)

PEF: Peak Expiratory Flow (ml/s)

Volbal:Difference between Inspiratory/Expiratory Volume

F:Flowrate (breaths per minute)

Vt: Tidal Volume（ml）

Mv: Minute Ventilation（ml）

AV: Accumulated Volume（ml）

EF50: Mid-tidal Expiratory Flow

EIP: End-inspiratory Pause (Invasive Method)

EEP: End-expiatory Pause (Invasive Method)

TR: Relax Time

PenH: Enhanced Pause

Rpef: Ratio of Time to Peak Expiratory Flow

Applications

1. Researches on various respiratory diseases, such as asthma, pulmonary fibrosis, lung injury, ARDS, lung cancer, etc.

2. Safety pharmacology: the effect of drugs on the respiratory system

3. Sleep apnea: monitor animal hypopnea, obstructive apnea, etc.

4. Environmental Toxicology: The impact of environmental pollutants on animal respiration

5. Inhalation Toxicology: Toxic effects of toxic substances on the respiratory system

6. High altitude medicine: The influence of high altitude environment on the respiratory system

7. Other occasions where respiratory parameters need to be evaluated

Configuration

Pertinent Literature

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021

[2]李宁, 李红鹏, 张本炎, 张柳, 沈继敏, 李庆云. "高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制" [J]. 中华医学杂志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022)

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

[15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

[16]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan.”Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice”[J]. Ecotoxicology and Environmental Safety 255 (2023) 114799 

[17]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J]. Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[18]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]. Front. Physiol. 14:1107782.

*Our company can provide customized services according to customers' special applications, requirements, as well as experimental services. Please kindly contact us for more information.

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