Detailed Introduction

The Whole-body Plethysmograph (WBP) developed by Tow-Int Tech is capable of measuring respiratory parameters of laboratory animals in conscious state and under unrestrained condition, such as respiratory rate, tide volume, Airway Hyperresponsiveness (AHR) test, etc.

Product Description

The Whole-body Plethysmograph (WBP) developed by Tow-Int Tech is capable of measuring respiratory parameters of laboratory animals in conscious state and under unrestrained condition, such as respiratory rate, tide volume, Airway Hyperresponsiveness (AHR) test, etc. WBP avoids the trauma of aerosols tube incision and the effects of anesthesia, making the whole experimental process simpler. It is used to study the reaction of animal models to drugs, the pharmacology and toxicology of respiratory drugs, especially suitable for a large badge animal models for rapid initial screening test, long-term follow-up research and repetitive screening.

Product Features

lNo operation is required and the instrument is easy to use

lMulti-channel simultaneous monitoring

lIt can be used in the study of respiration of animals in the natural state and long-term follow-up experiment, which is suitable for inital screening of drugs. 

lDrug aerosol atomization module is available

lAutomatic calibration function

lThere are drinking water and food ports for long-term continuous monitoring

lOptional functions are available, for example the measurements of ECG, blood pressure, body temperature, heart rate and other vital signs, which can be combined with implantable telemetry equipment

lEquipped with analysis software, data can be saved in Excel or TXT format

Test Parameters

• Ti: Inspiratory Time (s)

• Te: Expiratory Time (s)

• PIF: Peak Inspiratory Flow (ml/s)

• PEF: Peak Expiratory Flow (ml/s)

• Volbal:Difference between Inspiratory/Expiratory Volume

• F:Flowrate (breaths per minute)

• Vt:Tidal Volume（ml）

• Mv:Minute Ventilation（ml）

• AV:Accumulated Volume（ml）

• EF50: Mid-tidal Expiratory Flow

• EIP:End-inspiratory Pause (Invasive Method)

• EEP:End-expiatory Pause (Invasive Method)

• TR: Relax Time

• PenH:Enhanced Pause

• Rpef:Ratio of Time to Peak Expiratory Flow

Applications

1. Researches on various respiratory diseases, such as asthma, pulmonary fibrosis, lung injury, ARDS, lung cancer, etc.

2. Safety pharmacology: the effect of drugs on the respiratory system

3. Sleep apnea: monitor animal hypopnea, obstructive apnea, etc.

4. Environmental Toxicology: The impact of environmental pollutants on animal respiration

5. Inhalation Toxicology: Toxic effects of toxic substances on the respiratory system

6. High altitude medicine: The influence of high altitude environment on the respiratory system

7. Other occasions where respiratory parameters need to be evaluated

Configuration

End-Users List

Pertinent Literature

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021

[2]李宁, 李红鹏, 张本炎, 张柳, 沈继敏, 李庆云. "高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制" [J]. 中华医学杂志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022)

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

[15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

[16]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan.”Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice”[J] Ecotoxicology and Environmental Safety 255 (2023) 114799 

[17]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[18]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

[18]Haiyun Chen, Qiuyi Wang, Jie Li, Yuan Li, Ao Chen, Jiawen Zhou, Jingyu Zhao, Zhiyuan Mao, Zihao Zhou, Yue Wang, Rong Wan, Qing Li, Yongjie Zhang, Runqiu Jiang,Dengshun Miao, Jianliang Jin, “IFN Transcribed by IRF1 in CD4 + Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis” [J]. Aging and Disease, DOI: 10.14336/AD.2023.0320

[19]崔淦，李琦，舒方方，王汛江，李亚娟，杨莉，王峥涛，丁丽丽. "三七总皂苷通过抑制 NF-κB 转录活性改善 LPS 诱导小鼠急性肺损伤的研究". [J]. 药学学报. DOI： 10.16438/j.0513-4870.2022-0591

[20]IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice Dan Yang, Yi'na Li, Ting Liu, Ling Yang, Lixiu He, Tingxuan Huang, Lanlan Zhang, Jian Luo, Chuntao Liu 。First published: 29 March 2023  https://doi.org/10.1111/imm.13644   Jian Luo and Chuntao Liu contributed equally to this study.

[21]Meihao Peng, Jintao Li, Jie Zhou, Bowen Zhang, Jiaqing Liao, Di Yang, Yu Wang, Yixi Yang, Rui Li, Xue Tang, Qiuxia Lu, Qi Zhao,Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway,Phytomedicine,2023,154946,ISSN 0944-7113,https://doi.org/10.1016/j.phymed.2023.154946.

(https://www.sciencedirect.com/science/article/pii/S0944711323003070)

[22]Liu, Shengbin and Xiong, Anying and He, Xiang and Qin, Ran and Zhang, Lei and Luo, Li and Wang, Junyi and Jiang, Manling and Liu, Yao and Niu, Bin and Li, Guoping, Fine Particulate Matter Injury Airway Barrier Through Oxidative Stress Promotes the Demethylase FTO Regulating IKKβ m6A Modification and NF-κB Activation in Asthma (5/6/2022). Available at SSRN: https://ssrn.com/abstract=4104663 or http://dx.doi.org/10.2139/ssrn.4104663

[23]Xiaoqi Hu, Jingran Su, Mo Chen, Yikun Tu, Chunyan Wu, Xue Cao, Xinyi Yuan, Fang Zhang, Wenjun Ding,Macrophage-derived exosomal TNF-α promotes pulmonary surfactant protein expression in PM2.5-induced acute lung injury,Science of The Total Environment,Volume 892,2023,164732,ISSN 0048-9697,https://doi.org/10.1016/j.scitotenv.2023.164732.

[24]Ruan, D.; Yang, J.; Luo, Q.; Shi, Y.; Ding, L.; Wang, Z.; Wang, R.; Yang, L. The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition. Molecules 2023, 28, 2883.https://doi.org/10.3390/molecules28072883

[25]Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis。Jinru Zhang, Keqin Ji, Yuanmeng Ning, Lingna Sun, Mingrui Fan, Chunjie Shu, Ziqi Zhang, Tianyu Tu, Jingyun Cao, Feng Gao, and Yanzuo Chen  ACS Nano 2023 17 (11), 10113-10128   DOI: 10.1021/acsnano.2c12831

[26]Yize Yin,Chaohui Mu,Jiahui Wang,Yixuan Wang, Wenmin Hu,Wenjing Zhu,Xinjuan Yu,Wanming Hao,Yuxin Zheng, Qinghai Li, Wei Han. CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function,[J]2023-07-26,DOI: 10.3390/toxics11080646

[27]Gao-Xiang Wang,Jie Zhou,You-Mou Chen,Liang-Dong Xu,Shan-Ming Tao,Jia Ma,Ye-Han Sun,Ming-Sheng Wu,Zheng-Wei Chen,Yong-Fu Zhu,Ming-Ran Xie,Mechanism of electroacupuncture at acupoints of the lung meridian through PKA/PKC regulation of TRPV1 in chronic cough after lung surgery in guinea pigs,[J]PMC 2023 Apr 28; 15(4): 1848–1860.DOI:10.21037/jtd-23-409

[28]Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang,Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis,[J]Journal of Ethnopharmacolog，2023-08-01 ,DOI:10.1016/j.jep.2023.116983

*Our company can provide customized services according to customers' special applications, requirements, as well as experimental services. Please kindly contact us for more information.

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  Whole-body Plethysmography System for Rats

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  Whole-body Plethysmography System for Rats

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  Whole-body Plethysmography System for Mice

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  Whole-body Plethysmography System for Mice