Product Description

Ox-100 can simulate a continuous hypoxia environment in the animal chamber to create a hypoxia experimental models. The system has comprehensive monitoring parameters, for example, temperature, humidity, oxygen, and carbon dioxide. The Ox-100 animal hypoxia experiment system has excellent control performance, and the error of oxygen concentration is 0.1% during continuous hypoxia experiment.

The animal hypoxia chambers are customizable. The default chamber can hold 1 rat cage (or 2 mouse cages), and also provides large sizes, which can accommodate 2 rat cages and 4 cages. Rat cage. Other specifications can be customized. For hyperoxia experiments, please select model Ox-100HE.

Features

1.  Provide a stable hypoxic environment

2.  Chamber is made of fully transparent PMMA material to prevent the biological rhythm of animals from being affected by light

3. 7 -inch large-screen touch screen control, user-friendly interface, easy to operate

4. Monitoring parameters: temperature, humidity, oxygen O2 concentration, carbon dioxide concentration

5. Control accuracy: ± 0.1%

6.  Non-dispersive infrared ( NDIR ) carbon dioxide sensor, measuring range: 0 ~ 5000ppm

Application

Pulmonary hypertension, kidney disease research, tumor research, cardiovascular disease research, retinopathy, sports medicine research, OSAHS, brain development and neurobiology, stem cell research, medical research, etc.

Reference

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling" . [J]. Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J, Zhu Y , Zhu X. “Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys.” [J]. Front. Physiol. 12:690496. doi: 10.3389/fphys.2021.690496

[8]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions.” [J]. Psychopharmacology. 

[9]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling.” [J]. Front. Microbiol. 12:820691

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[12]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[13]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[14]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[15]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation.” [J]. Front. Mol. Neurosci. 16:1155047.

[16]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension.” [J]. Cell Death Discovery (2023) 9:98.

[17]Chen-Yu Jiang,Li-Wei Wu,Yi-Wei Liu,Bei Feng, Lin-Cai Ye,Xu Huang,Yang-Yang He,Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, and Yi Yan.Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension,[J]Frontiers in Immunology,28 June 2023,Volume 14 - 2023, DOI: 10.3389/fimmu.2023.1153573

[18]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast Enhanced Ultrasonography of Kidney in Chronic Intermittent Hypoxia Rat Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147

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  Animal Hypobaric Chamber (Thermostatic Version)