Product Description 

The head-out plethysmography system (Head-Out Plethysmography) adopts a special design to separate the neck of the small animal from the body, and expose the mouth and nose to the outside, and measure the gas volume and pressure changes in the chamber containing the thorax in real time. Glaab et al. used mACh stimulation on asthmatic mice, and took the mAh amount (EF50) when the mid-expiratory flow (EF50) dropped by 55% as an index to indicate the sensitivity of the bronchial response. The study proved that EF50 has a better correlation with RL and CL The correlation can better reflect the mechanical dynamics changes of the respiratory system.

Features 

l During the measurement process using the Head-out Plethysmography System, the animal remains conscious and does not require anesthesia, which avoids the impact of traumatic tracheotomy and anesthesia, allowing a simple and fast experimental process, and is suitable for long-term follow-up research.

l In addition, the system can be expanded and connected to an nebulized drug delivery device to administer nebulized drugs to animals to establish models of respiratory diseases such as cough and asthma models. The system can detect and record changes in vital respiratory parameters and airway hyper-responses during the excitation process to evaluate bronchoconstriction.

lNo surgery is required and the operation is simple.

lAnimals are conscious and results are not affected by anesthesia and surgery.

lIt is possible to do long-term follow-up experiments on the same animal.

lEquipped with an nebulizer. (can be selected according to experimental requirements)

lIt can be combined with synchronous measurement of other signals, such as body temperature, blood pressure, ECG, etc.

Testing parameters

Ti：inspiratory time（s）                                                                                           Te：exhalation time（s）

PIF：maximum inspiratory flow rate（ml/s）                        PEF：maximum expiratory flow rate（ml/s）

Volbal：inspiratory time/expiratory time                                                                                         F：respiratory rate（次/min）

Vt：tidal volume（ml）                                   Mv：minute ventilation volume（ml）

AV：accumulative volume（ml）                              EF50：the corresponding expiratory flow rate when exhaling 50% of the volume（ml/s）

EIP：end-inspiratory pause time                                                                                                       EEP：end-expiratory pause time

TR：relaxation time                                                                                                                             PenH：enhanced pause

Rpef：relative time

Applicable Fields

l Asthma 

l Lung Fibrosis

l COPD

l Acute Respiratory Disorders

l Model Development 

l Safety Assessment

l Toxicology

Model Selection

Customer List

Reference

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  Whole-body Plethysmography System for Rats

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  Whole-body Plethysmography System for Rats

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  Whole-body Plethysmography System for Mice

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  Whole-body Plethysmography System for Mice